Over-the-counter pain relievers These include acetaminophen (Tylenol) and noncopyrightal anti-inflammatory drugs (NSAIDs) like aspirin, ibuprofen (Advil, Motrin), and naproxen (Aleve, Naprosyn). NSAIDs can reduce fever and pain, and swelling from arthritis or muscle sprains. However, Relieves acute pain they can cause stomach upset or ulcers in som